Chronic Kidney Disease in Children
We have several ongoing epidemiologic and translational research studies that examine risk factors, early diagnosis and prognosis of kidney disease in children. Several of these are multicenter studies done in collaboration with Yale University, University of Cincinnati and academic centers in Canada. The following protocols had children enrolled and are being followed longitudinally. Data and samples from these studies are available for ancillary studies:
- In TRIBE-AKI, over 300 children undergoing congenital cardiac surgery were enrolled during hospitalization and the cohort has been followed for seven years through phone calls, medical chart review and data linkages.
- The Assessment, Serial Evaluation, and Subsequent Sequelae in AKI (ASSESS-AKI) cohort has annual in-person follow-up of over 100 children for five years.
- We are also measuring urine and serum biomarkers of kidney injury, inflammation, repair, and fibrosis from the samples of the children enrolled in the CKD in Children (CKiD) cohort
Greenberg JH, Whitlock R, Zhang WR, Thiessen-Philbrook HR, Zappitelli M, Devarajan P, Eikelboom J, Kavsak PA, Devereaux PJ, Shortt C, Garg AX, Parikh CR; TRIBE-AKI Consortium. Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery. Pediatr Nephrol 2015; 30(9):1519-27.
Funding Information for this Project
The TRIBE-AKI Consortium is supported by the NIH/NHLBI (R01HL085757, “Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney Injury”) and the ASSESS AKI study is sponsored by the NIDDK (U01DK082185, “Progression of Acute Kidney Injury to Chronic Kidney Disease”)